A disruption defect implies that there is destruction of a part of
a fetus that had initially developed normally. Disruptions
usually affect several different tissues within a defined
anatomical region. Amniotic band disruption after early
rupture of the amnion is a well-recognised entity, causing
constriction bands that can lead to amputations of digits and
limbs. Sometimes more extensive disruptions occur, such as
facial clefts and central nervous system defects. Interruption of
the blood supply to a developing part from other causes will
also cause disruption due to infarction with consequent atresia.
The prognosis is determined by the severity of the physical
defect. As the fetus is genetically normal and the defects are
caused by an extrinsic abnormality the risk of recurrence is
small.
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